I would be wary of the fine print and do extensive research. Sometimes accessibility, as defined by ADA, is not what we may think of comfortable accessibility. A Florida room is accessible to some and may meet the minimum requirements and yet not be ideal for someone with low trunk control that needs more than that. Being able to have someone talk through needs is so important. Plus, if something is needed or goes wrong, who are you calling at Hotel.Com.
For a day- it is probably okay. For a week in a place that you are not familiar with – buyer beware.